Melatonin ameliorates hyperglycaemia-induced renal inflammation by inhibiting the activation of TLR4 and TGF-β1/Smad3 signalling pathway.
Jie Wei, Yan Wang, Xiangming Qi, Zhe Fan, Yonggui Wu
Abstract
, melatonin treatment reduced the cell proliferation, inflammatory factors releasing, TLR4 and TGF-β1/Smad3 signaling pathway. Our findings indicated that melatonin may provide a new perspective intervention to halt the hyperglycemia-induced inflammatory response of DN.
Topics & Concepts
MelatoninEndocrinologyInternal medicineDiabetic nephropathyInflammationMedicineFibrosisKidneyBirth, Development, and HealthCircadian rhythm and melatoninDietary Effects on Health