Rhodium( <scp>iii</scp> )-catalyzed direct C–H activation of 2-aryl-3 <i>H</i> -indoles: a strategy for 4-heteroaryl pyrazole synthesis
Zi Yang, Luo Ji, Wenbo Zhang, Jieni Lei, Chaoshui Liu, Yaqian Li
Abstract
-indoles and diazopyrazolones through the rhodium(III)-catalyzed C-H bond activation has been achieved. This redox-neutral strategy features powerful reactivity, tolerates various functional groups, and proceeds with moderate yields under mild reaction conditions.
Topics & Concepts
RhodiumCatalysisArylChemistryMedicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms