Functional Characterization of the m <sup>6</sup> A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite
Ameya Sinha, Sebastian Baumgarten, Amy Jodine Distiller, Emma McHugh, Patty Chen, Meetali Singh, Jessica M. Bryant, Jiaqi Liang, Germano Cecere, Peter C. Dedon, Peter R. Preiser, Stuart A. Ralph, Artur Scherf
Abstract
Infection with the unicellular eukaryotic pathogen Plasmodium falciparum causes malaria, a mosquito-borne disease affecting more than 200 million and killing 400,000 people each year. Underlying the asexual replication within human red blood cells is a tight regulatory network of gene expression and protein synthesis.
Topics & Concepts
Plasmodium falciparumMalariaParasite hostingPlasmodium (life cycle)BiologyPathogenVirologyGeneHuman pathogenHuman diseaseCell biologyComputational biologyMicrobiologyGeneticsImmunologyComputer scienceWorld Wide WebRNA modifications and cancerRNA and protein synthesis mechanismsCancer-related gene regulation