IFNγ signaling integrity in colorectal cancer immunity and immunotherapy
Wan Du, Timothy L. Frankel, Michael Green, Weiping Zou
Abstract
The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ICB. Moreover, we discuss how to target IFNγ signaling to inform novel clinical trials to treat patients with colorectal cancer.
Topics & Concepts
ImmunotherapyColorectal cancerImmunityCancer immunotherapyMedicineCancer researchImmunologyCancerImmune systemInternal medicineImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersCytokine Signaling Pathways and Interactions