Long non-coding RNA CCAT1 promotes colorectal cancer progression by regulating miR-181a-5p expression
Anquan Shang, Weiwei Wang, Chenzheng Gu, Wei Chen, Wenying Lu, Zujun Sun, Dong Li
Abstract
<0.05). CCAT1 promoted cell proliferation, growth and mobility by targeting miR-181a-5p and the silence of CCAT1 increased the cell apoptosis. Same effect was observed in an in vivo xenograft model, which the tumor size and pro-tumor proteins were significantly diminished by knocking down of CCAT1.
Topics & Concepts
Long non-coding RNABiologyRNANon-coding RNAColorectal cancerCancer researchSenescenceMetastasisCoding (social sciences)Cell biologyBioinformaticsGeneticsComputational biologyCancerGeneStatisticsMathematicsCancer-related molecular mechanisms researchRNA modifications and cancerCircular RNAs in diseases