Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress
Xiangyun Qiao, Wen Li, Zhiwei Zheng, Chang Liu, Liping Zhao, Yingzi He, Huawei Li
Abstract
. Knocking down HMGB1 and RAGE achieved specific protective effects. Altogether, inhibiting HMGB1/RAGE axis can reverse the increase of ROS accumulation, the activation of apoptosis, and the production of inflammatory reactions after cisplatin injury. FPS-ZM1 could resist the ototoxicity of cisplatin by suppressing the HMGB1/RAGE signal pathway, and it may be considered the new otoprotective potential strategy for hearing loss.
Topics & Concepts
Rage (emotion)HMGB1OtotoxicityOxidative stressInflammationCisplatinPharmacologyApoptosisChemistryReactive oxygen speciesMedicineCancer researchImmunologyBiologyInternal medicineBiochemistryChemotherapyNeuroscienceAdvanced Glycation End Products researchNF-κB Signaling PathwaysNeutrophil, Myeloperoxidase and Oxidative Mechanisms