Biohybrid catalysis in biomedicine
Xiaoye Li, Yu Zhang, Ao He, Qiang Li, Siyu Wang, Jingyang Shan, Shengke Li, Dongliang Yang, Guan Wu, Weijun Xiu, Yuxin Liu, Heng Dong
Abstract
Biohybrid catalysis has emerged as a transformative approach in biomedicine, which integrate biological components (such as enzymes, proteins, cytomembrane, or cells) with non-biological synthetic materials (such as nanozymes, metal complexes, or polymers) to address the limitations of traditional catalytic systems in terms of catalytic performance, biocompatibility, operational conditions, and specificity. This synergy enhances catalytic performance, biocompatibility, stability, and specificity, overcoming the limitations of traditional catalysts in biomedical applications. The article delves into the design and integration strategies of biohybrid catalysts, as well as their applications in antimicrobial therapy, biosensing and diagnostics, cancer treatment, treatment for reactive oxidative specie (ROS) overload-related diseases, tissue engineering, neural machine interfaces, drug delivery and prodrug activation. The future of biohybrid catalysis holds immense promise for transforming biomedical research and clinical practice. As the field continues to advance, it is expected that these hybrid systems will become increasingly integral to developing innovative therapies and diagnostic tools, ultimately improving patient outcomes.