Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing
Yangcan Chen, Yanping Hu, Xinge Wang, Shengqiu Luo, Ning Yang, Yi Chen, Zhikun Li, Qi Zhou, Wei Li
Abstract
) has been further engineered to minimize off-target effects. Our work provides an expandable and efficacious method for engineering Cas nucleases for robust mammalian genome editing.
Topics & Concepts
CRISPRGenome editingGenome engineeringComputational biologyComputer scienceBiologyGeneticsGeneCRISPR and Genetic EngineeringInnovation and Socioeconomic Development