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A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids

Christopher Below, Joanna Kelly, Alexander Brown, Jonathan D. Humphries, Colin Hutton, Jingshu Xu, Brian Y. Lee, Célia Cintas, Xiaohong Zhang, Victor Hernandez‐Gordillo, Linda Stockdale, Matthew A. Goldsworthy, Joe Geraghty, Lucy Foster, Derek O’Reilly, Barbara Schedding, Janet A. Askari, Jessica Burns, Nigel W. Hodson, Duncan L. Smith, Catherine Lally, Garry Ashton, David Knight, Mironov Aa, Antonia Banyard, Johannes A. Eble, Jennifer P. Morton, Martin J. Humphries, Linda G. Griffith, Claus Jørgensen

2021Nature Materials191 citationsDOIOpen Access PDF

Topics & Concepts

OrganoidPancreatic cancerStromal cellExtracellular matrixCell biologyTumor microenvironmentLamininBiologyIn vivoIn vitroSelf-healing hydrogelsIntegrinCancer researchChemistryCancerCellBiochemistryGeneticsTumor cellsOrganic chemistryBiotechnologyCancer Cells and Metastasis3D Printing in Biomedical ResearchCellular Mechanics and Interactions
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids | Litcius