Protein Binding: A Fuzzy Concept
Michael P. Williamson
Abstract
Our understanding of protein binding interactions has matured significantly over the last few years, largely as a result of trying to make sense of the binding interactions of intrinsically disordered proteins. Here, we bring together some disparate ideas that have largely developed independently, and show that they can be linked into a coherent picture that provides insight into quantitative aspects of protein interactions, in particular that transient protein interactions are often optimised for speed, rather than tight binding.
Topics & Concepts
Computational biologyProtein–protein interactionPlasma protein bindingBiologyComputer scienceGeneticsCell biologyProtein Structure and DynamicsEnzyme Structure and FunctionMicrobial Metabolic Engineering and Bioproduction