Mechanisms of reduced cerebral blood flow in cerebral edema and elevated intracranial pressure
Yuliya Zadka, Omer Doron, Guy Rosenthal, Ofer Barnea
Abstract
Study goal was to elucidate the role of "bulk flow" of ISF through brain parenchyma. A model was developed to simulate fluid shifts in brain edema, ICP elevation, and their effect on CBF. Bulk flow resistance affected by edema elevates ICP and reduces CBF. Bulk flow affects transmural pressure and volume distribution in brain compartments. Changes in bulk flow resistance result in increase of venous resistance to flow and decrease in CBF.
Topics & Concepts
Cerebral blood flowIntracranial pressureCerebral edemaMedicineAnesthesiaBrain edemaCerebral perfusion pressureCerebrovascular CirculationBlood flowCardiologyTraumatic Brain Injury and Neurovascular DisturbancesCerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies