Advancing beyond the twists and turns of T cell exhaustion in cancer
Verena van der Heide, Étienne Humblin, Abishek Vaidya, Alice O. Kamphorst
Abstract
Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction. Better understanding of heterogeneity and dynamics of exhausted CD8 T cells will guide novel therapies that modulate T cell differentiation to achieve more effective antitumor responses.
Topics & Concepts
Tumor microenvironmentT cellCancer researchCD8CellStimulationCytotoxic T cellCancerCell biologyMedicineImmunologyAntigenBiologyImmune systemTumor cellsInternal medicineBiochemistryIn vitroCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionCAR-T cell therapy research