Optimization of Fluconazole Dosing for the Prevention and Treatment of Invasive Candidiasis Based on the Pharmacokinetics of Fluconazole in Critically Ill Patients
J. Boonstra, Anne‐Grete Märtson, Indy Sandaradura, Jos G. W. Kosterink, Tjip S. van der Werf, Deborah Marriott, Jan G. Zijlstra, Daan J. Touw, Jan‐Willem C. Alffenaar
Abstract
The efficacy of fluconazole is related to the area under the plasma concentration-time curve (AUC) over the MIC of the microorganism. Physiological changes in critically ill patients may affect the exposure of fluconazole, and therefore dosing adjustments might be needed.
Topics & Concepts
FluconazoleDosingPharmacokineticsCritically illMedicineInvasive candidiasisIntensive care medicinePharmacologyAntifungalDermatologyAntifungal resistance and susceptibilityAntibiotics Pharmacokinetics and EfficacyPneumocystis jirovecii pneumonia detection and treatment