Atopic Dermatitis and Autism Spectrum Disorders: Common Role of Environmental and Clinical Co-Factors in the Onset and Severity of Their Clinical Course
Rossella Casella, Andrea Miniello, Federica Buta, Mona‐Rita Yacoub, Eustachio Nettis, Giovanni Pioggia, Sebastiano Gangemi
Abstract
Increasing evidence suggests an association between atopic dermatitis, the most chronic inflammatory disease of the skin, and autism spectrum disorders, which are a group of neurodevelopmental diseases. Inflammation and immune dysregulation associated with genetic and environmental factors seem to characterize the pathophysiological mechanisms of both conditions. We conducted a literature review of the PubMed database aimed at identifying the clinical features and alleged risk factors that could be used in clinical practice to predict the onset of ASD and/or AD or worsen their prognosis in the context of comorbidities.
Topics & Concepts
Atopic dermatitisImmune dysregulationAutismContext (archaeology)MedicineDiseaseImmunologyImmune systemPsychiatryPathologyBiologyPaleontologyDermatology and Skin DiseasesTransgenic Plants and ApplicationsAsthma and respiratory diseases