Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders
John Malona, Claudio Chuaqui, Boris M. Seletsky, Lisa Beebe, Susan Cantin, Daniel van Kalken, Kelly Fahnoe, Zhigang Wang, Beth Browning, Hilary Szabo, Louise A. Koopman, Tamás Oravecz, Joseph J. McDonald, Francisco Ramírez‐Valle, Rajula Gaur, Kofi A. Mensah, Michael A. Thomas, Jamie N. Connarn, Haiqing Hu, Matthew D. Alexander, Alan F. Corin
Topics & Concepts
ChemistryTachyphylaxisp38 mitogen-activated protein kinasesPharmacologyGeldanamycinHsp27PhosphorylationBiochemistryProtein kinase AHeat shock proteinHsp90BiologyHsp70GeneMelanoma and MAPK PathwaysDrug-Induced Hepatotoxicity and ProtectionProtein Kinase Regulation and GTPase Signaling