Lupeol inhibits the proliferation and migration of MDA-MB-231 breast cancer cells <i>via</i> a novel crosstalk mechanism between autophagy and the EMT
Xin Zhang, Zhan-Wang Gao, Kehan Chen, Qing-Yuan Zhuo, Meixian Chen, Jiansong Wang, Xiao‐Ping Lai, Lingli Wang
Abstract
. Additional intrinsic mechanism studies revealed that lupeol might induce autophagy by inhibiting the Akt-mTOR pathway, and activating an autophagy inhibited epithelial-mesenchymal transition (EMT). This study demonstrated that lupeol could inhibit TNBC cells by inducing autophagy, suggesting lupeol as a potential treatment alternative or as a dietary supplement for TNBC, as well as offering novel insights into the anti-cancer effect of lupeol.
Topics & Concepts
LupeolAutophagyPI3K/AKT/mTOR pathwayTriple-negative breast cancerCancer researchBreast cancerChemistrySignal transductionCancerBiologyMedicineBiochemistryApoptosisInternal medicineGenomics, phytochemicals, and oxidative stressTannin, Tannase and Anticancer ActivitiesLipid metabolism and biosynthesis