Water-Mediated Catalytic Decarboxylation Enabled Polysubstituted Furans and Allylic Alcohols with Exclusive (<i>E</i>)-Configurations
Yulian Yang, Linhong Zuo, Kun Wei, Wusheng Guo
Abstract
A water-mediated catalytic decarboxylation process toward the formation of polysubstituted furans and (E)-allylic alcohols has been reported. This protocol features wide functional group tolerance, easy operation, and only CO2-byproduct generation. These reactions can be performed on a large scale open to air under extremely ambient conditions. A range of control experiments revealed the crucial role of the water for the successful conversions as well as the origin of the chemoselectivity and exclusive stereoselectivity.
Topics & Concepts
DecarboxylationAllylic rearrangementChemistryChemoselectivityStereoselectivityCatalysisFunctional groupOpen airCombinatorial chemistryOrganic chemistryReaction conditionsArchitectural engineeringPolymerEngineeringCatalytic Alkyne ReactionsAsymmetric Hydrogenation and CatalysisCyclopropane Reaction Mechanisms