Distributed implantation of a flexible microelectrode array for neural recording
Chunrong Wei, Yang Wang, Weihua Pei, Xinyong Han, Longnian Lin, Zhiduo Liu, Gege Ming, Ruru Chen, Pingping Wu, Xiaowei Yang, Zheng Li, Yijun Wang
Abstract
Flexible multichannel electrode arrays (fMEAs) with multiple filaments can be flexibly implanted in various patterns. It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands. This study proposed a strategy for reducing the microelectrode volume with integrated packaging. An implantation system was developed specifically for semiautomatic distributed implantation. The feasibility and convenience of the fMEA and implantation platform were verified in rodents. The acute and chronic recording results provied the effectiveness of the packaging and implantation methods. These methods could provide a novel strategy for developing fMEAs with more filaments and recording sites to measure functional interactions across multiple brain regions.