Treatment of cutaneous sarcoidosis with tofacitinib 2% ointment and extra virgin olive oil
Mariam Alam, Victoria Fang, Misha Rosenbach
Abstract
Sarcoidosis is a chronic multisystem inflammatory disorder characterized by granuloma formation. Macrophage accumulation and activation in sarcoidosis is thought to be mediated by CD4+ helper T cells via interferon γ (IFNγ) and other cytokines. IFNγ acts through the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway.1 Immunosuppressants such as corticosteroids, methotrexate, and tumor necrosis factor-α inhibitors are used to treat sarcoidosis, but these medications may have significant adverse effects and are variably effective.
Topics & Concepts
TofacitinibMedicineJanus kinaseSarcoidosisCutaneous SarcoidosisSTAT proteinTumor necrosis factor alphaImmunologyAdverse effectInterferonGranulomaMethotrexateCancer researchDermatologySignal transductionCytokineSTAT3Internal medicineRheumatoid arthritisChemistryBiochemistryMast cells and histamineAutoimmune Bullous Skin DiseasesSarcoidosis and Beryllium Toxicity Research