Comparative Results of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus Assays for Detection of Tuberculosis Infection in Clinical Samples
Dongju Won, Jung Yong Park, Hyon-Suk Kim, Younhee Park
Abstract
The QuantiFERON-TB Gold plus (QFT-Plus) assay, an interferon gamma (IFN-γ) release assay (IGRA), was recently introduced as the next version of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay for diagnosing latent tuberculosis (TB). Whereas the QFT-GIT assay uses only one TB tube that induces a cell-mediated immune (CMI) response of CD4 + T cells, the QFT-Plus has an additional TB antigen 2 tube (TB2) for the CMI response of CD8 + T and CD4 + T cells, in addition to a TB antigen 1 (TB1) tube for the CMI response of CD4 + T cells only.
Topics & Concepts
TuberculosisAntigenMedicineQuantiFERONGold standard (test)Immune systemCD8Mycobacterium tuberculosisInterferon gammaLatent tuberculosisVirologyImmunologyInternal medicinePathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisInfectious Diseases and Tuberculosis