Dearomative [3 + 2] cycloaddition reaction of nitrobenzothiophenes with nonstabilized azomethine ylides
Kai‐Kai Wang, Yanxin Xie, Yanli Li, Rongxiang Chen, Zhan‐Yong Wang
Abstract
]pyrroles in good yields (up to 92%) under mild reaction conditions. In addition, a gram-scale experiment and the synthetic transformation of the cycloadduct further highlighted the synthetic utility. The relative configurations of the typical products were clearly confirmed by X-ray crystallography.
Topics & Concepts
CycloadditionAzomethine ylideChemistryCombinatorial chemistryMedicinal chemistryOrganic chemistry1,3-Dipolar cycloadditionCatalysisSynthesis and Catalytic ReactionsOrganic Chemistry Cycloaddition ReactionsCyclopropane Reaction Mechanisms