MSCs-Derived miR-150-5p-Expressing Exosomes Promote Skin Wound Healing by Activating PI3K/AKT Pathway through PTEN
Cheng Xiu, Huining Zheng, Manfei Jiang, Jiaxu Li, Yanhong Zhou, Lan Mu, Weisong Liu
Abstract
Background and Objectives: The goal of this study was to investigate the mechanism of mesenchymal stem cell (MSC)-derived microRNA (miR)-150-5p-expressing exosomes in promoting skin wound healing through activating PI3K/AKT pathway by PTEN. Methods and Results: -induced injury in HaCaT cells. PTEN was a target gene of miR-150-5p. MiR-150-5p regulated PI3K/AKT pathway through PTEN. Conclusions: MSCs-derived miR-150-5p-expressing exosomes promote skin wound healing by activating PI3K/AKT pathway through PTEN.
Topics & Concepts
HaCaTPTENMicrovesiclesPI3K/AKT/mTOR pathwayProtein kinase BCancer researchmicroRNAWound healingTransfectionChemistryCell migrationFlow cytometryMesenchymal stem cellApoptosisCell growthCell biologyCellMolecular biologyBiologyImmunologyIn vitroBiochemistryGeneExtracellular vesicles in diseaseWound Healing and Treatments