Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders
Junichi Yamamoto, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa
Abstract
and their subsequent degradation. This discovery was a breakthrough in the current rapid development of protein-degrading agents because clarification of the mechanism of action of thalidomide derivatives has demonstrated the clinical value of these compounds. This review provides an overview of the mechanism of action of thalidomide and its derivatives and describes perspectives for protein degraders.
Topics & Concepts
ThalidomideAction (physics)Mechanism (biology)Computer scienceComputational biologyChemistryBiologyMedicinePhilosophyEpistemologyPhysicsInternal medicineQuantum mechanicsMultiple myelomaProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways