Exosomal transfer leads to chemoresistance through oxidative phosphorylation-mediated stemness phenotype in colorectal cancer
Jinhai Deng, Teng Pan, Chunxin Lv, Lulu Cao, Lifeng Li, Xingang Zhou, Gang Li, Huanxin Li, José M. Vicencio, Yihan Xu, Fengxiang Wei, Yazhou Wang, Zaoqu Liu, Guanglin Zhou, Mingzhu Yin
Abstract
Our data suggests that exosomal circ_0001610-induced OXPHOS plays an important role in chemoresistance and supports a therapeutical potential of circ_0001610 inhibitors in the treatment of oxaliplatin-resistant colorectal cancer by manipulating cell stemness.
Topics & Concepts
Oxidative phosphorylationMicrovesiclesExosomeCancer researchPhosphorylationCancer stem cellStem cellBiologyMitochondrionMetastasisCancerCell biologyChemistrymicroRNABiochemistryGeneGeneticsCircular RNAs in diseasesExtracellular vesicles in diseaseMicroRNA in disease regulation