Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships
Marc H. Scheetz, Gwendolyn Pais, Thomas P. Lodise, Steven Y. C. Tong, Joshua S. Davis, J. Nicholas O’Donnell, Jiajun Liu, Michael Neely, Walter C. Prozialeck, Peter C. Lamar, Nathaniel J. Rhodes, Thomas L Holland, Sean N. Avedissian
Abstract
= 291]). A logit-link model was used to calculate the multiplicative factors between the probability of AKI from clinical studies and in the rat. The rat was 2.7 to 4.2 times more sensitive to AKI between AUCs of 199.5 and 794.3 mg·h/liter, respectively.
Topics & Concepts
VancomycinPharmacokineticsLiterMedicineLogistic regressionPharmacologyUrologyInternal medicineBiologyStaphylococcus aureusGeneticsBacteriaAntimicrobial Resistance in StaphylococcusAntibiotics Pharmacokinetics and EfficacyClostridium difficile and Clostridium perfringens research