A heteroditopic NHC and phosphine ligand supported ruthenium(<scp>ii</scp>)-complex: an effective catalyst for the <i>N</i>-alkylation of amides using alcohols
S. N. R. Donthireddy, Vivek Singh, Arnab Rit
Abstract
A heteroditopic Ru( ii )-bis-NHC complex in combination with dppe was developed as an effective catalyst system (0.2 mol% loading) for the N -alkylation of amides and selective mono-/di-alkylation of 4-aminobenzamide derivatives in excellent yields.
Topics & Concepts
PhosphineAlkylationCatalysisRutheniumChemistryLigand (biochemistry)Medicinal chemistryCombinatorial chemistryOrganic chemistryReceptorBiochemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisSynthetic Organic Chemistry Methods