Molecular acceptor engineering to precisely design a NIR type I photosensitizer for efficient PDT-based synergistic therapy
Ziqi Zou, Yili Xie, Jiaxing Wan, Qing Wan, Jianwen Tian, Xiaoyong Zhang, Yen Wei
Abstract
Three near-infrared red type I PSs (named TP1, TP2, and TP3) were synthesized by adjusting their electron acceptors. TP3 can achieve efficient PDT-based synergistic therapy in cells via glutathione depletion.
Topics & Concepts
PhotosensitizerPhotodynamic therapyAcceptorMolecular engineeringMaterials sciencePhotochemistryChemistryNanotechnologyCombinatorial chemistryOrganic chemistryPhysicsCondensed matter physicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies