The Intracellular Number of Magnetic Nanoparticles Modulates the Apoptotic Death Pathway after Magnetic Hyperthermia Treatment
Lilianne Beola, Laura Asín, Catarina Roma‐Rodrigues, Yilian Fernández‐Afonso, Raluca M. Fratila, David Serantes, Sergiu Ruta, R.W. Chantrell, Alexandra R. Fernandes, Pedro V. Baptista, Jesús M. de la Fuente, Valeria Grazú, Lucía Gutiérrez
Abstract
mRNA ratio and low caspase-8 activity. In contrast, at higher concentrations of internalized magnetic nanoparticles (1-7.5 pg Fe/cell), the extrinsic route was observed through the increased activity of caspase-8. Nevertheless, both mechanisms may coexist at intermediate iron concentrations. Knowledge on the different mechanisms of cell death triggered after the magnetic hyperthermia treatment is fundamental to understand the biological events activated by this procedure and their role in its effectiveness.