Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer
Jianxia Li, Cheng Wu, Huabin Hu, Ge Qin, Xueqian Wu, Fan Bai, Jianwei Zhang, Yue Cai, Yan Huang, Chao Wang, Jiaqi Yang, Yizhao Luan, Zehang Jiang, Jiayu Ling, Zehua Wu, Yaoxu Chen, Zhi Xie, Yanhong Deng
Topics & Concepts
Cancer researchImmune systemStromal cellMicrosatellite instabilityImmune checkpointTumor microenvironmentCD8Proinflammatory cytokineColorectal cancerDNA mismatch repairImmunotherapyBiologyT cellImmunologyMedicineCancerInflammationBiochemistryGeneMicrosatelliteGeneticsAlleleCancer Immunotherapy and BiomarkersSingle-cell and spatial transcriptomicsGenetic factors in colorectal cancer