Safety of menstrual blood-derived stromal cell transplantation in treatment of intrauterine adhesion
Qiyuan Chang, Siwen Zhang, Pingping Li, Zhengwei Yuan, Jichun Tan
Abstract
BACKGROUND: Intrauterine adhesion (IUA) can cause serious damage to women's reproductive health, yet current treatment methods are difficult to achieve satisfactory results. In our previous studies, we demonstrated that menstrual-derived stromal stem cells (MenSCs), with high proliferative capacity and self-renewal ability, have a powerful therapeutic effect in patients with severe IUA. However, safety assessment of MenSCs transplantation is essential for its further application. AIM: intrauterine transplantation in a rat model of IUA, with a focus on toxicity and tumorigenicity. METHODS: . RESULTS: . CONCLUSION: There is no acute, sub-chronic, or chronic poisoning, infection, tumorigenesis, or endometriosis in rats with IUA after MenSC transplantation. The above results suggest that intrauterine transplantation of MenSCs is safe for endometrial treatment.