An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility
Suguru Iwata, Momo Morikawa, Yosuke Takei, Nobutaka Hirokawa
Abstract
3'UTR disrupted KIF17 synthesis induced by fear memory retrieval, leading to impairment in extinction of fear memory. These results indicate that the regulation of the KIF17 transport is driven by the single dendrite-restricted cycle of degradation and synthesis that underlies cognitive flexibility.
Topics & Concepts
Flexibility (engineering)Cognitive flexibilityCognitionDegradation (telecommunications)Regeneration (biology)NeuroscienceComputer scienceBusinessPsychologyCell biologyBiologyEconomicsTelecommunicationsManagementPancreatic function and diabetesNeuroscience and Neuropharmacology ResearchEndoplasmic Reticulum Stress and Disease