The Crucial Role of Inflammation and the Immune System in Colorectal Cancer Carcinogenesis: A Comprehensive Perspective
Antonio Manuel Burgos-Molina, Teresa Téllez Santana, Maximino Redondo, María José Bravo Romero
Abstract
Chronic inflammation drives the growth of colorectal cancer through the dysregulation of molecular pathways within the immune system. Infiltration of immune cells, such as macrophages, into tumoral regions results in the release of proinflammatory cytokines (IL-6; IL-17; TNF-α), fostering tumor proliferation, survival, and invasion. Tumors employ various mechanisms to evade immune surveillance, effectively 'cloaking' themselves from detection and subsequent attack. A comprehensive understanding of these intricate molecular interactions is paramount for advancing novel strategies aimed at modulating the immune response against cancer.
Topics & Concepts
Immune systemInflammationProinflammatory cytokineColorectal cancerCarcinogenesisImmunologyImmune surveillanceCancer researchCancerBiologyMedicineGeneticsIL-33, ST2, and ILC PathwaysCancer Immunotherapy and BiomarkersImmune cells in cancer