Continuous flow synthesis of azobenzenes via Baeyer–Mills reaction
Jan H. Griwatz, Anne Kunz, Hermann A. Wegner
Abstract
Azobenzene, as one of the most prominent molecular switches, is featured in many applications ranging from photopharmacology to information or energy storage. In order to easily and reproducibly synthesize non-symmetric substituted azobenzenes in an efficient way, especially on a large scale, the commonly used Baeyer-Mills coupling reaction was adopted to a continuous flow setup. The versatility was demonstrated with a scope of 20 substances and the scalability of this method exemplified by the synthesis of >70 g of an azobenzene derivative applied in molecular solar thermal storage (MOST) systems.
Topics & Concepts
AzobenzeneChemistryScope (computer science)Continuous flowScalabilityCombinatorial chemistryDerivative (finance)Flow chemistryNanotechnologyOrganic chemistryMoleculeBiochemical engineeringComputer scienceCatalysisMaterials scienceEngineeringDatabaseFinancial economicsProgramming languageEconomicsInnovative Microfluidic and Catalytic Techniques InnovationPhotochromic and Fluorescence ChemistryNanomaterials for catalytic reactions