Metal-free oxoammonium salt-mediated C(sp<sup>3</sup>)–H oxidative Ugi-azide multicomponent reaction
Niklas Lohmann, Vesna Milovanović, Dariusz G. Piekarski, Olga Garcı́a Mancheño
Abstract
as a practical azide source. The reaction proceeds at room temperature and without the need of acid additives, allowing for the use of sensitive substrates, while minimizing isocyanide polymerization to provide the desired heterocycle-tetrazole products in synthetically useful yields (up to 99%).
Topics & Concepts
ChemistryTetrazoleIsocyanideAzideSalt (chemistry)Combinatorial chemistryPolymerizationMetalOxidative phosphorylationHydrideOrganic chemistryPolymerBiochemistrySynthesis of Tetrazole DerivativesMulticomponent Synthesis of HeterocyclesClick Chemistry and Applications