In vitro cytotoxicity and druglikeness of pyrazolines and pyridines bearing benzofuran moiety
Asma S. Al‐Wasidi, Ashraf S. Hassan, Ahmed M. Naglah
Abstract
A series of pyrazolines and pyridines bearing benzofuran moiety (M1-M10) were synthesized for evaluation of their in vitro cytotoxicity against MCF-7 and HepG2 cell lines. Furthermore, in silico drug-likeness study was carried out. The result of the cytotoxicity of M1-M10 showed that some compounds displayed cytotoxic activity against MCF-7 and HepG2 cells. An assessment of in silico drug-likeness study of M1-M10 illustrates that some compounds showed an agreement to the Lipinski, Ghose, Veber, Egan, and Muegge rules with orally bioavailable.
Topics & Concepts
BenzofuranMoietyCytotoxicityChemistryBearing (navigation)In vitroStereochemistryMedicinal chemistryBiochemistryComputer scienceArtificial intelligenceSynthesis and biological activityMulticomponent Synthesis of HeterocyclesChemical synthesis and pharmacological studies