18F-FDG Uptake Outperforms 68Ga-FAPI in Mediastinal NUT Carcinoma
Kan Wang, Jun-mei Pu, Xiang Ke, Ya Liu, Zhanwen Huang
Abstract
NUT carcinoma is a rare and highly aggressive tumor with nuclear protein in the testis gene rearrangement. Herein, we describe the different findings of 68 Ga-FAPI-04 and 18 F-FDG PET/CT in a 31-year-old man with mediastinal NUT carcinoma with lymph node and pleura metastasis. In our case, 68 Ga-FAPI-04 PET/CT was not superior to FDG in detecting primary lesions and lymph node metastases of mediastinal NUT, but it is possible to produce beneficial value in the evaluation of pleura metastasis.
Topics & Concepts
MedicineNutCarcinomaMediastinal lymph nodeLymph nodeRadiologyPathologyLymphPrimary tumorMetastatic carcinomaMediastinal tumorMediastinumRespiratory diseaseNuclear medicineCancerPeptidase Inhibition and AnalysisProtein Degradation and InhibitorsUbiquitin and proteasome pathways