Convenient Multicomponent One‐Pot Synthesis of 2‐Iminothiazolines and 2‐Aminothiazoles Using Elemental Sulfur Under Aqueous Conditions
András Németh, Bence Marlok, Attila Domján, Qinghe Gao, Xinya Han, György M. Keserű, Péter Ábrányi‐Balogh
Abstract
Abstract Herein, we present a novel one‐pot aqueous reaction for the synthesis of 2‐iminothiazolines and 2‐aminothiazoles using isocyanides, amines, sulfur, and 2′‐bromoacetophenones. The three‐component preparation of thioureas is followed by the one‐pot cyclization leading to the heterocyclic product. This efficient and mild procedure features excellent step‐ and atom‐economy and enables the chromatography‐free preparation of diversely substituted 2‐iminothiazoline and 2‐aminothiazole derivatives.
Topics & Concepts
ChemistrySulfurOne-pot synthesisAqueous solutionOrganic chemistryCombinatorial chemistryAtom economyCatalysisSulfur-Based Synthesis TechniquesMulticomponent Synthesis of HeterocyclesSynthesis and biological activity