Phosphatidylserine-deficient small extracellular vesicle is a major somatic cell-derived sEV subpopulation in blood
A. Matsumoto, Yuki Takahashi, Kosuke Ogata, Shimpei Kitamura, Naoki Nakagawa, Aki Yamamoto, Yasushi Ishihama, Yoshinobu Takakura
Abstract
-sEVs could indeed be the key player in sEV-mediated intercellular communication, a good target for sEV-based diagnosis, and a potent candidate for sEV-based drug delivery. Our findings bring a paradigm shift in the understanding of the biology and translational applications of sEVs.
Topics & Concepts
PhosphatidylserineSomatic cellExtracellular vesiclesBiologyCell biologyIntracellularExtracellularPopulationVesicleBlood cellMolecular biologyImmunologyBiochemistryGeneMedicineMembraneEnvironmental healthPhospholipidExtracellular vesicles in diseaseMicroRNA in disease regulationPhagocytosis and Immune Regulation