Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons
Corina Nagy, Malosree Maitra, Arnaud Tanti, Matthew Suderman, Jean‐François Théroux, Maria Antonietta Davoli, Kelly Perlman, Volodymyr Yerko, Yu Chang Wang, Shreejoy J. Tripathy, Paul Pavlidis, Naguib Mechawar, Jiannis Ragoussis, Gustavo Turecki
Topics & Concepts
NeuroscienceTranscriptomeDorsolateral prefrontal cortexPrefrontal cortexExcitatory postsynaptic potentialBiologyOligodendrocyteMajor depressive disorderPsychologyGene expressionCentral nervous systemMyelinGeneAmygdalaGeneticsInhibitory postsynaptic potentialCognitionSingle-cell and spatial transcriptomicsNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders