Sustained <i>in vitro</i> interferon-beta release and <i>in vivo</i> toxicity of PLGA and PEG-PLGA nanoparticles
Andrea Fodor-Kardos, Ádám Kiss, Katalin Monostory, Tivadar Feczkó
Abstract
Interferon-beta-1a (IFN-β-1a) can diminish the symptoms of relapsing-remitting multiple sclerosis.
Topics & Concepts
PLGAChemistryIn vivoNanoparticlePEG ratioMicroparticleToxicityDrug deliveryIn vitroNuclear chemistryDrug carrierBovine serum albuminPharmacologyBiophysicsMaterials scienceChromatographyChemical engineeringNanotechnologyBiochemistryOrganic chemistryMedicineBiologyBiotechnologyEconomicsFinanceEngineeringAdvanced Drug Delivery SystemsImmunotherapy and Immune ResponsesRNA Interference and Gene Delivery