Dynamic white matter changes in recovered COVID-19 patients: a two-year follow-up study
Sihong Huang, Xianglin Zhou, Wei Zhao, Yanyao Du, Danhui Yang, Yijie Huang, Yanjing Chen, Huiting Zhang, Guang Yang, Jun Liu, Hong Luo
Abstract
Recovered COVID-19 patients showed longitudinal recovery trends of white matter. But also had persistent white matter abnormalities at two years after discharge. Inflammation levels in the acute stage may be considered predictors of cognition and white matter integrity, and the white matter microstructure acts as a biomarker of cognitive function in recovered COVID-19 patients. These findings provide an objective basis for early clinical intervention.
Topics & Concepts
White matterDiffusion MRICognitionLongitudinal studyMedicineWechsler Adult Intelligence ScaleAnalysis of varianceCoronavirus disease 2019 (COVID-19)Fractional anisotropyInternal medicineMagnetic resonance imagingPediatricsPathologyPsychiatryRadiologyDiseaseInfectious disease (medical specialty)Long-Term Effects of COVID-19Advanced Neuroimaging Techniques and ApplicationsCerebrospinal fluid and hydrocephalus