Prevaccination Glycan Markers of Response to an Influenza Vaccine Implicate the Complement Pathway
Rui Qin, Guanmin Meng, Smruti Pushalkar, Michael A. Carlock, Ted M. Ross, Christine Vogel, Lara K. Mahal
Abstract
) and a decrease in high mannose glycans among high responders, which were not observed in nonresponders. These data suggest that the immune system may actively modulate glycosylation as part of its effort to establish effective protection postvaccination.
Topics & Concepts
GlycanGlycosylationImmunologyInfluenza vaccineVaccinationImmune systemBiologyAntigenComplement systemHemagglutinin (influenza)Classical complement pathwayImmunityVirologyGlycoproteinGeneticsInfluenza Virus Research StudiesComplement system in diseasesvaccines and immunoinformatics approaches