Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING
Natalia Zamorano Cuervo, Audray Fortin, Elise Caron, Stéfany Chartier, Nathalie Grandvaux
Abstract
prevented hyperactivation of STING by causing a conformational change associated with the formation of inactive polymers containing intermolecular disulfide bonds. This finding should aid the design of therapies targeting STING that are relevant to autoinflammatory disorders, immunotherapies, and vaccines.
Topics & Concepts
CysteineChemistrySignal transducing adaptor proteinStingRedoxProteomicsMechanism (biology)Ligand (biochemistry)BiochemistryBiophysicsCell biologySignal transductionBiologyEnzymeReceptorOrganic chemistryEpistemologyEngineeringAerospace engineeringPhilosophyGeneinterferon and immune responsesViral Infections and VectorsImmune Response and Inflammation