The Generalized Pustular Psoriasis Physician Global Assessment (GPPGA) score: online assessment and validation study of a specific measure of GPP disease activity
A. David Burden, H. Bachelez, Siew Eng Choon, Slaheddine Marrakchi, Tsen‐Fang Tsai, H. Turki, Akimichi Morita, Mark Lebwohl, Robert Bissonnette, Min Zheng, Milan J. Anadkat, Alexander A. Navarini, Ming Tang, Christian Thoma, Kristina Callis Duffin
Abstract
Generalized pustular psoriasis (GPP), a rare and potentially life-threatening neutrophilic skin disease, is characterized by recurrent flares of pustulation on nonacral skin with associated erythema, crusting and scaling. There are no agreed or validated measurements for assessing GPP severity or symptom improvement; clinically validated endpoints that incorporate key manifestations of GPP, and are meaningful and reliable for the evaluation of treatment response, are needed.
Topics & Concepts
MedicinePsoriasisGeneralized pustular psoriasisErythemaDermatologyDiseaseSeverity of illnessPustular psoriasisInternal medicinePsoriasis: Treatment and PathogenesisAutoimmune Bullous Skin DiseasesDermatology and Skin Diseases