Cobalt-Catalyzed Deprotection of Allyl Carboxylic Esters Induced by Hydrogen Atom Transfer
Nan Li, Yizhen Gui, Mengqi Chu, Mengdi You, Xiaohan Qiu, Hejia Liu, Shiang Wang, Meng Deng, Bao‐Ming Ji
Abstract
A brief, efficient method has been developed for the removal of the allyl protecting group from allyl carboxylic esters using a Co(II)/TBHP/(Me2SiH)2O catalytic system. This facile strategy displays excellent chemoselectivity, functional group tolerance, and high yields. This transformation probably occurs through the hydrogen atom transfer process, and a Co(III)–six-membered cyclic intermediate is recommended.
Topics & Concepts
ChemistryChemoselectivityCatalysisCobaltHydrogen atomFunctional groupHydrogenGroup (periodic table)Combinatorial chemistryMedicinal chemistryOrganic chemistryPolymerAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsChemical Synthesis and Reactions