AMPK increases expression of ATM through transcriptional factor Sp1 and induces radioresistance under severe hypoxia in glioblastoma cell lines
Takuma Hashimoto, Yusuke Urushihara, Yasuhiko Murata, Yohei Fujishima, Yoshio Hosoi
Topics & Concepts
RadioresistanceAMPKGene knockdownHypoxia (environmental)ChemistryCell biologyCancer researchSp1 transcription factorCell cultureBiologyGene expressionProtein kinase APhosphorylationGeneBiochemistryOrganic chemistryOxygenPromoterGeneticsMitochondrial Function and PathologyCancer, Hypoxia, and MetabolismFOXO transcription factor regulation