Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity
Runzhe Song, Yue Wang, Minghui Wang, Ruixuan Gao, Teng Yang, Song Yang, Cai‐Guang Yang, Yongsheng Jin, Siyuan Zou, Jianfeng Cai, Renhua Fan, Qiuqin He
Topics & Concepts
ChemistryhERGTopoisomerase IVCardiotoxicitySubstituentContext (archaeology)EffluxMultiple drug resistancePharmacologyCombinatorial chemistryStereochemistryAntibioticsToxicityDNA gyraseBiochemistryGeneEscherichia coliBiophysicsBiologyOrganic chemistryPotassium channelPaleontologyAntimicrobial Resistance in StaphylococcusCancer therapeutics and mechanismsAntibiotics Pharmacokinetics and Efficacy