A novel red AIE fluorescent probe for ratiometric detection of carbon monoxide <i>in vitro</i> and <i>in vivo</i>
Shuai Huang, Xiaohui Liu, Jing Hou, Min Liu, Ting Luo, Xueyan Huang, Fei Chen, Jie Dong, Wenbin Zeng
Abstract
, the probe emitted red fluorescence at 630 nm. Furthermore, we successfully demonstrated the potential of THBTA-CO in visualizing both exogenous and endogenous CO in living cells. Significantly, THBTA-CO was effectively employed to image CO in lipopolysaccharide (LPS)-induced oxidative stress in mice. These findings convincingly establish THBTA-CO as a promising fluorescent probe for CO sensing and imaging, thereby facilitating a better understanding of CO's role in biomedical research.
Topics & Concepts
In vivoFluorescenceIn vitroCarbon monoxideMaterials scienceNanotechnologyBiophysicsChemistryBiologyOpticsBiochemistryPhysicsBiotechnologyCatalysisHeme Oxygenase-1 and Carbon MonoxideNeonatal Health and BiochemistryNeuroscience of respiration and sleep