Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents
Wenxue Sun, Fusheng Sun, Junjun Meng, Xiaohua Cao, Shiyuan Zhao, Changshui Wang, Luning Li, Pei Jiang
Topics & Concepts
ChemistryPodophyllotoxinPI3K/AKT/mTOR pathwayVimentinMTT assayPTENProtein kinase BIC50ApoptosisMicrotubuleCancer cellSmall moleculeCell biologyCancer researchIn vitroBiochemistryCancerStereochemistryBiologyImmunohistochemistryGeneticsImmunologyPlant-derived Lignans Synthesis and BioactivityCancer Mechanisms and TherapySynthesis and biological activity