Toward an understanding of regulatory T cells in COVID‐19: A systematic review
Mahsa Rahimzadeh, Nadereh Naderi
Abstract
A more detailed understanding of Treg cells in COVID-19 infection will broaden our knowledge of the COVID-19 immunopathology and give us more insight into the curative immune-based strategies. We systematically searched electronic databases (PubMed, Google Scholar, EMBASE) and identified 18 eligible studies. Despite the inconsistencies between the results, we observed a trend toward decreasing Treg levels in severe COVID-19 patients. This finding underlines the hypothesis that Tregs play a role in the pathogenesis of COVID-19. Further studies on Tregs' functional aspects are necessary to illustrate Tregs' potential role in COVID-19 disease.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ImmunopathologyImmunologyDiseasePandemicImmune systemVirologyMedicineBiologyInfectious disease (medical specialty)PathologyOutbreakImmune Cell Function and InteractionT-cell and B-cell ImmunologyDiabetes and associated disorders